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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK4
All Species:
23.03
Human Site:
S259
Identified Species:
46.06
UniProt:
P11802
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11802
NP_000066.1
303
33730
S259
R
G
P
R
P
V
Q
S
V
V
P
E
M
E
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
S259
R
G
P
R
P
V
Q
S
V
V
P
E
M
E
E
Dog
Lupus familis
XP_538252
303
33686
T259
R
G
P
R
P
V
Q
T
V
V
P
E
M
E
E
Cat
Felis silvestris
Mouse
Mus musculus
P30285
303
33732
S259
R
G
P
R
P
V
Q
S
V
V
P
E
M
E
E
Rat
Rattus norvegicus
P35426
303
33780
S259
R
G
P
R
P
V
Q
S
V
V
P
E
M
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001007893
326
36832
K264
R
P
A
Q
P
I
E
K
F
V
P
D
I
D
D
Frog
Xenopus laevis
Q91727
319
35666
K259
R
T
Q
Q
P
V
D
K
F
V
P
E
I
D
A
Zebra Danio
Brachydanio rerio
NP_001071245
297
33310
R255
N
F
S
P
Q
S
P
R
P
I
T
D
C
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_391955
457
50351
A415
Y
R
Q
A
K
S
F
A
T
I
I
S
D
L
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
D264
T
G
Q
R
S
F
L
D
L
V
Q
E
I
C
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
T251
W
Q
A
Q
D
L
A
T
V
V
P
N
L
D
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
T251
W
K
P
T
D
L
E
T
F
V
P
N
L
D
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
97
N.A.
94.7
95
N.A.
N.A.
65.3
72
71.9
N.A.
N.A.
35.2
N.A.
48.7
Protein Similarity:
100
N.A.
99.6
97.6
N.A.
97
97.3
N.A.
N.A.
75.7
79.9
80.1
N.A.
N.A.
50.3
N.A.
60.8
P-Site Identity:
100
N.A.
100
93.3
N.A.
100
100
N.A.
N.A.
26.6
40
0
N.A.
N.A.
0
N.A.
26.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
N.A.
73.3
60
13.3
N.A.
N.A.
13.3
N.A.
40
Percent
Protein Identity:
N.A.
43.8
N.A.
45.5
N.A.
N.A.
Protein Similarity:
N.A.
62.7
N.A.
64
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
9
0
0
9
9
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
9
0
% C
% Asp:
0
0
0
0
17
0
9
9
0
0
0
17
9
34
9
% D
% Glu:
0
0
0
0
0
0
17
0
0
0
0
59
0
42
42
% E
% Phe:
0
9
0
0
0
9
9
0
25
0
0
0
0
0
0
% F
% Gly:
0
50
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
0
0
17
9
0
25
0
0
% I
% Lys:
0
9
0
0
9
0
0
17
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
17
9
0
9
0
0
0
17
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
42
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
0
17
0
0
17
% N
% Pro:
0
9
50
9
59
0
9
0
9
0
75
0
0
0
25
% P
% Gln:
0
9
25
25
9
0
42
0
0
0
9
0
0
0
0
% Q
% Arg:
59
9
0
50
0
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
0
9
17
0
34
0
0
0
9
0
0
0
% S
% Thr:
9
9
0
9
0
0
0
25
9
0
9
0
0
0
0
% T
% Val:
0
0
0
0
0
50
0
0
50
84
0
0
0
9
0
% V
% Trp:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _